Hm, that's a hard question. I have to admit that I'm a Nintendo fanboy. So...
NES was great, SNES was also great. Unfortunately I didn't have a N64 and a Gamecube. Wii was great and Wii U - let's say - could be great (still waiting for Zelda...).
I have a GameBoy Color and a Nintendo DS. The GameBoy Color really sucks because it has no backlight. So it's hard to get the light right in a way you can see something on the screen.
Sometimes I'm wondering how we were able to finish all of these games. Nowadays you have a save point every 5 screens. And if you play the old games in the emulator you can save at any point.
BTW: That was one of the aspects what I liked about Prey: You couldn't die in that game. I mean you could, but you were able to get back each time without saving and loading.