The first time I watched FMA, the 'Cry Of The Chimera' (7th) episode just went by and made me sad. I'm watching the series once more and when I came up to the episode, I almost didn't want to watch it because it was so depressing. It was sorta unbearable, and eventually landed up shedding a tear.
Then - Episode 25 - Farewell Ceremony: "why, why are they burying daddy? daddy's got work to do and he cant do it if they cover him up...daddy has work to do he told me so...why are they burying daddy, why are they burying daddy?" - roughly, that's what his daughter says ... I'm dreading getting to this episode on the re-watch ...
Chobits and Wolf's Rain, which again played with my heart.
Gungrave had many moments for me ... towards the end - talking of the part where Brandon protects Harry and is on the floor ... when Harry asks why he protected him after all the pain he'ad caused ... and Brandon says "Because I couldn't harm you" or something in that effect (can't remember the exact dialogue)
One Piece has it's own share with the dog ChuChu ... then when Sanji's just about to leave the floating restaurant with Luffy, and at that moment, the old man says "Sanji, don't get a cold..." ... I think I broke down the same time as Sanji did >_> ...
The start of Blood+ when George told Saya to kill him using her blood ... that was just awful ... and then at the end, just when Haji confesses his love for Saya and dies protecting her ... made me feel miserable to say the least.